Optical Nanomaterial-Based Detection of Biomarkers in Liquid Biopsy
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Advances in Nanobiosensors during the COVID-19 Pandemic |
| Authors: Y. J. Kim, J. Min* Journal: Nano Convergence Publisher: Springer Nature Volume: 11 Article Number: 3 Page: 1-57 Publication Date: January 11, 2024 DOI: https://doi.org/10.1186/s40580-023-00410-5 Synopsis: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was an unprecedented threat. Because the pandemic highlights the weak spots of the current diagnostic toolbox, interest in nanobiosensors has intensified. We summarize the advances during the pandemic using the criteria of point-of-care (POC) diagnostics along with COVID-specific issues. Key Results: In a total of 158 studies, much effort has been made to meet the ASSURED criteria of POC diagnostics regarding affordable (A), sensitive (S), specific (S), user-friendly (U), rapid and robust (R), equipment-free (E), and deliverable to the end-user (D) standards. In addition, we evaluated COVID-specific issues, multiplexed detection (M), on-circulating variant (O), real-time connectivity (R), and equity for global health (E). |
Hydrogel-Based Technologies in Liquid Biopsy for the Detection of Circulating Clinical Markers: Challenges and Prospects
| Authors: Y. J. Kim, J. Min* Journal: Analytical and Bioanalytical Chemistry Publisher: Springer Nature Volume: TBD Page: 1-14 Publication Date: November 15, 2023 DOI: https://doi.org/10.1007/s00216-023-05025-7 Synopsis: The great promise of liquid biopsy is often limited due to its conceptual and practical limitations. Hydrogels consist of hydrophilic and biocompatible polymeric networks that would aid in isolating, protecting, and analyzing their low-abundant and short-lived circulating biomarkers. Key Results: Hydrogel-based technologies in liquid biopsies have kept increasing since 2015, and most of them were published during the last five years. By helping to overcome biological, technical, and clinical obstacles, the adoption of the hydrogel may generate a link between challenges in liquid biopsy and current analytical status. |
Single-Nanoparticle-Based Digital SERS Sensing Platform for the Accurate Quantitative Detection of SARS-CoV‐2
Authors: J. E. Shim, Y. J. Kim, J. H. Choe, T. G. Lee, E. A. You* Journal: ACS Applied Materials and Interfaces Publisher: American Chemical Society Volume: 14, Issue: 34 Page: 38459-38470 Publication Date: August 11, 2022 DOI: https://doi.org/10.1021/acsami.2c07497 Synopsis: Develop the gold core-shell nanoprobe having a bumpy shell structure for the SERS-based detection of the SARS-CoV-2 spike proteins. Key Results: Both ultrasensitive and quantitative detection was achieved with a subpicomolar limit of detection and over seven orders of dynamic range. |
Property Modulation of the Alginate-based Hydrogel via Semi-Interpenetrating Polymer Network (semi-IPN) with Poly(vinyl alcohol)
Authors: Y. J. Kim, J. Min* Journal: International Journal of Biological Macromolecules Publisher: Elsevier Volume: 193, Part B Page: 1068-1077 Publication Date: November 19, 2021 DOI: https://doi.org/10.1016/j.ijbiomac.2021.11.069 Synopsis: The weakness of the polysaccharide-based hydrogel was covered and modulated by the hybridization with poly(vinyl alcohol) with the semi-Interpenetrating polymer network (semi-IPN). Key Results: The blending and crosslinking pathway modulated the property of the hybrid hydrogel. So, this enables us to control the hydrogels' physiological stability under practical or engineering conditions. |
Circulating Tumor Marker Isolation with the Chemically Stable and Instantly Degradable (CSID) Hydrogel ImmunoSpheres
Authors: Y. J. Kim, Y.-H. Cho,* J. Min, S.-W. Han Journal: Analytical Chemistry Publisher: American Chemical Society Volume: 93, Issue: 02 Page: 1100-1109 Publication Date: December 18, 2020 DOI: https://doi.org/10.1021/acs.analchem.0c04152 Synopsis: Demonstrate simple, versatile, and time-efficient assay methods for circulating tumor markers (Circulating tumor cells and exosomes) using chemically stable and instantly degradable hydrogel. Key Results: Two different circulating markers were obtained within 3 hours through parallel and integrated methods in a practical setting. |
High-Purity Capture and Release of Circulating Exosomes Using an Exosome-Specific Dual-patterned Immunofiltration (ExoDIF) Device
Authors: Y.-T. Kang#, Y. J. Kim#, J. Bu, Y.-H. Cho*, S.-W. Han, and B.-I. Moon (#co-first author) Journal: Nanoscale Publisher: Royal Society of Chemistry Volume: 9, Issue: 36 Page: 13495-13505 Publication Date: August 16, 2017 DOI: https://doi.org/10.1039/C7NR04557C Synopsis: Demonstrate an anti-CD63 antibody-based immunofiltration device for the enrichment of circulating exosomes. The device presents simple and rapid exosome recovery method by the role of cleavable linkers. Key Results: The present device successfully separated the exosome-sized vesicle. The results indicate that the exosome level of cancer patients was significantly higher than that of healthy donors. ✤ The 3rd chapter of my Ph.D. Dissertation |
Author
Young Jun Kim, Ph.D.
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